The contracture produced by sodium removal in the non-pregnant rat myometrium.
نویسندگان
چکیده
منابع مشابه
Influence of the sodium gradient on contractile activity in pregnant rat myometrium.
The effects of varying the sodium gradient-either by lowering [Na+]o or by increasing [Na+]i on the electromechanical properties of pregnant rat uterine smooth muscle were studied. In normal tissues, complete removal of external sodium ions (choline, Tris or sucrose as substitutes) induced a strong and maintained contraction which was dependent on the presence of extracellular calcium ions, and...
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Desensitization of beta2-adrenoceptor function in non-pregnant rat myometrium is modulated by sex steroids.
The effects of in vivo treatment with estrogen and progesterone on isoproterenol-induced uterine relaxation and beta(2)-adrenoceptor (beta(2)AR) mRNA production in non-pregnant rat myometrium were investigated. Whether homologous myometrial desensitization of beta(2)AR function was dependent on or modulated by the two steroids was also examined. Estrogen treatment alone or in combination with p...
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The objective of the present study was to further elucidate our previous observation that beta2-adrenoceptor activation induces oxytocin receptor (OTR) expression in rat myometrium. We wanted to investigate whether the mechanism behind this effect was under the influence of gonadal steroids. Ovariectomized non-pregnant rats were treated with estrogen, progesterone or a combination of both for 3...
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The precise factors involved in the transition of the relaxed pregnant uterus to the contractile state at the onset of parturition remain unclear, but it is accepted that cAMP-generating pathways contribute to uterine relaxation. We have previously reported an increased expression of the adenylyl cyclase (AC)-stimulating protein Galphas in human myometrium during gestation, with a corresponding...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1983
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1983.sp014498